Systematic understanding the mechanisms of vitiligo pathogenesis and its treatment by Qubaibabuqi formula

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• 作者：Tianli Pei^a ; ^b ; Chunli Zheng^a ; Chao Huang^a ; Xuetong Chen^a ; Zihu Guo^a ; Yingxue Fu^a ; Jianling Liu^b ; Yonghua Wang^a ; ^{yh_wang@nwsuaf.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Butin (PubChem CID ; 92775) ; Butein (PubChem CID ; 5281222) ; Galangin (PubChem CID ; 5281616) ; Psoralen (PubChem CID ; 6199) ; Kaempferol (PubChem CID ; 5282102) ; Cholesterol (PubChem CID ; 5997) ; Isopsoralen (PubChem CID ; 10658)
• 刊名：Journal of Ethnopharmacology
• 出版年：2016
• 出版时间：22 August 2016
• 年：2016
• 卷：190
• 期：Complete
• 页码：272-287
• 全文大小：1744 K

文摘

Vitiligo is a depigmentation disorder, which results in substantial cosmetic disfigurement and poses a detriment to patients' physical as well as mental. Now the molecular pathogenesis of vitiligo still remains unclear, which leads to a daunting challenge for vitiligo therapy in modern medicine. Herbal medicines, characterized by multi-compound and multi-target, have long been shown effective in treating vitiligo, but their molecular mechanisms of action also remain ambiguous.

Materials and methods

Here we proposed a systems pharmacology approach using a clinically effective herb formula as a tool to detect the molecular pathogenesis of vitiligo. This study provided an integrative analysis of active chemicals, drug targets and interacting pathways of the Uygur medicine Qubaibabuqi formula for curing Vitiligo.

Results

The results show that 56 active ingredients of Qubaibabuqi interacting with 83 therapeutic proteins were identified. And Qubaibabuqi probably participate in immunomodulation, neuromodulation and keratinocytes apoptosis inhibition in treatment of vitiligo by a synergistic/cooperative way.

Conclusions

The drug-target network-based analysis and pathway-based analysis can provide a new approach for understanding the pathogenesis of vitiligo and uncovering the molecular mechanisms of Qubaibabuqi, which will also facilitate the application of traditional Chinese herbs in modern medicine.