Replication-Dependent Unhooking of DNA Interstrand Cross-Links by the NEIL3 Glycosylase
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- 作者：Daniel R. Semlow1 ; 4 ; Jieqiong Zhang1 ; 4 ; 5 ; Magda Budzowska1 ; 6 ; Alexander C. Drohat2 ; Johannes C. Walter1 ; 3 ; 7 ; johannes_walter@hms.harvard.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：DNA interstrand cross-link ; ICL ; NEIL3 ; FANCI ; FANCD2 ; psoralen ; abasic site ; Fanconi anemia
- 刊名：Cell
- 出版年：2016
- 出版时间：6 October 2016
- 年：2016
- 卷：167
- 期：2
- 页码：498-511.e14
- 全文大小：7239 K
文摘
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Distinct mechanisms resolve different DNA interstrand cross-links (ICLs)
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Psoralen and abasic site ICL repair is independent of DNA breaks and FANCI-FANCD2
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The NEIL3 DNA glycosylase resolves psoralen and abasic site ICLs
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FANCI-FANCD2-dependent ICL resolution predominates in the absence of NEIL3