Tryptophan pathway alterations in the postpartum period and in acute postpartum psychosis and depression
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- 作者：Cato Veena ; c.veen@erasmusmc.nl" class="auth_mail" title="E-mail the corresponding author ; Aye Mu Myintb ; Karin M. Burgerhouta ; Markus J. Schwarzc ; Gregor Schü ; tzec ; Steven A. Kushnera ; Witte J. Hoogendijka ; Hemmo A. Drexhaged ; Veerle Berginka ; e
- 关键词：Postpartum ; Psychosis ; Depression ; Tryptophan ; Kynurenine ; Immunology ; Serotonin
- 刊名：Journal of Affective Disorders
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：189
- 期：Complete
- 页码：298-305
- 全文大小：605 K
文摘
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Healthy postpartum women have an increased breakdown of tryptophan towards kynurenine.
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Kynurenine is lower in patients with postpartum mood disorders compared to controls.
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Postpartum women have low neuroprotective KynA levels and high neurotoxic 3HK levels.
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KynA and 3HK levels are similar in postpartum patients and postpartum controls.