Chiral resolution of salbutamol in plasma sample by a new chiral ligand-exchange chromatography method after its extraction with nano-sized imprinted polymer
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- 作者：Taher Alizadeha ; talizadeh@ut.ac.ir" class="auth_mail" title="E-mail the corresponding author ; taa_55@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Amir Naser Shamkhalib
- 关键词：(l)-Alanine ; Chiral separation ; Salbutamol ; C8 column ; Ligand exchange ; Nano-sized imprinted polymer
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：1009-1010
- 期：Complete
- 页码：96-106
- 全文大小：3142 K
文摘
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Salbutamol enantiomers were resolved by the chiral ligand exchange chromatography.
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(l)-Alanine and Cu(II) were used as chiral dopant and complexing ion, respectively.
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The kind of cooper salt was found to be crucial factor in the enantioseparation.
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DFT was employed to substantiate the separation mechanism and anion effect.
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Sulbutamol-imprinted polymer was used for sample preparation before its analysis.