Polarizing the Neuron through Sustained Co-expression of Alternatively Spliced Isoforms
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- 作者：Karen Yap1 ; Yixin Xiao2 ; 3 ; Brad A. Friedman4 ; H. Shawn Je2 ; 3 ; Eugene V. Makeyev1 ; 5 ; eugene.makeyev@kcl.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：10 May 2016
- 年：2016
- 卷：15
- 期：6
- 页码：1316-1328
- 全文大小：4388 K
文摘
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Alternative 3′-terminal isoforms often become co-expressed in developing neurons
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Ptbp1/2-dependent and constitutive mechanisms ensure co-expression of Cdc42 isoforms
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Controlled utilization of Cdc42 exon 7 in neurons is required for proper axonogenesis
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Exon-6-containing isoform of Cdc42 promotes formation of dendritic spines in vivo