Perturbation of energy metabolism by fatty-acid derivative AIC-47 and imatinib in BCR-ABL-harboring leukemic cells
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- 作者：Haruka Shinoharaa ; t3501002@edu.gifu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Minami Kumazakia ; Yosuke Minamib ; Yuko Itoc ; Nobuhiko Sugitoa ; Yuki Kuranagaa ; Kohei Taniguchia ; Nami Yamadaa ; Yoshinori Otsukic ; Tomoki Naoed ; Yukihiro Akaoa
- 关键词：BCR-ABL ; Imatinib ; Warburg effect ; Fatty-acid oxidation ; CPT1C
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：1 February 2016
- 年：2016
- 卷：371
- 期：1
- 页码：1-11
- 全文大小：2664 K
文摘
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Imatinib strongly suppresses Warburg effect through the down-regulation of PTBP1.
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Fatty-acid oxidation (FAO) supports glucose-independent survival in imatinib-treated cells.
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Inactivation of BCR-ABL activates compensatory FAO.
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AIC-47 perturbs both glycolysis and FAO.
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The inhibition of glycolysis and FAO can be effective for the CD34+ fraction.