Development of a BRET-based tool-set to monitor PPIn dynamics in live cells
EGFR and moderate M3R activation lead to increased PtdIns4P level at the PM.
RTK and GPCR stimulation can lead to PI4KA activation through a PKC-dependent manner.
PM PtdIns4P synthesis is critical for Ins(1,4,5)P3 signaling upon receptor activation.