PTEN is required to maintain luminal epithelial homeostasis and integrity in the adult mammary gland
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- 作者：Amy N. Shorea ; amy.shore@bcm.edu" class="auth_mail" title="E-mail the corresponding author ; Chi-Hsuan Changb ; Oh-Joon Kwona ; Matthew C. Westonc ; Mei Zhangd ; Li Xina ; Jeffrey M. Rosena
- 关键词：Epithelial ; Homeostasis ; Mammary ; PTEN
- 刊名：Developmental Biology
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：409
- 期：1
- 页码：202-217
- 全文大小：16254 K
文摘
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PTEN regulates proliferation of mammary luminal epithelial cells.
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PTEN regulates mitotic spindle orientation in mammary luminal epithelial cells.
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PTEN loss in mammary luminal epithelial cells does not confer apoptosis resistance.
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Luminal epithelial PTEN loss is not sufficient to promote mammary tumor progression.