Rapamycin prevents, but does not reverse, aberrant migration in Pten knockout neurons
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- 作者：Stephanie A. Getz ; Tyrone DeSpenza Jr ; Meijie Li ; Bryan W. Luikart ; Bryan.W.Luikart@Dartmouth.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pten ; Rapamycin ; Migration ; Autism ; Focal cortical dysplasia
- 刊名：Neurobiology of Disease
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：93
- 期：Complete
- 页码：12-20
- 全文大小：2144 K
文摘
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Pten loss results in somal hypertrophy and aberrant neuronal migration in the dentate gyrus.
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Rapamycin, a mTor inhibitor, prevents and reverses somal hypertrophy in Pten knockout neurons.
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Rapamycin can only prevent and not reverse aberrant migration in Pten knockout neurons.
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Aberrant migration following loss of Pten occurs through mTorC1 and not mTorC2.