The PIM1 kinase promotes prostate cancer cell migration and adhesion via multiple signalling pathways
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- 作者：Niina M. Santioa ; b ; Maria Salmelac ; Heidi Arolaa ; Sini K. Eerolaa ; 1 ; Jyrki Heinoc ; Eeva-Marja Rainioa ; Pä ; ivi J. Koskinena ; paivi.koskinen@utu.fi" class="auth_mail" title="E-mail the corresponding author
- 关键词：PIM1 ; GSK3B ; FoxP3 ; PTGS2 ; Integrins ; Prostate cancer
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：342
- 期：2
- 页码：113-124
- 全文大小：4822 K
文摘
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GSK3B and FOXP3 are identified as PIM substrates regulating cell motility.
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Their anti-migratory activities are relieved by PIM-dependent phosphorylation.
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PIM-promoted prostate cancer cell migration is dependent on PTGS2 expression.
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PIM kinases also regulate integrin-mediated cell adhesion.