Oxidation inhibits PTH receptor signaling and trafficking

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• 作者：Juan A. Ardura^a ; ^b ; ^c ; Veró ; nica Alonso^a ; ^c ; Pedro Esbrit^b ; Peter A. Friedman^c ; ^{paf10@pitt.edu}
• 关键词：PTH ; PTH receptor ; Hydrogen peroxide (PubChem CID ; 784) ; Oxidative stress ; Signaling ; Trafficking
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：1019-1024
• 全文大小：562 K
• 卷排序：482

文摘

Reactive oxygen species are involved in organ-specific diseases, where PTHR is functionally relevant. PTH receptor signaling and trafficking are inhibited by hydrogen peroxide. Reactive oxygen species are putative targets in receptor diseases associated with oxidative stress.