Protein tyrosine kinase 7 is essential for tubular morphogenesis of the Wolffian duct
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- 作者：Bingfang Xua ; Angela M. Washingtona ; Raquel Fantin Domeniconia ; b ; Ana Clá ; udia Ferreira Souzaa ; c ; Xiaowei Lua ; Ann Sutherlanda ; Barry T. Hintona ; bth7c@virginia.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ptk7 ; Tubular morphogenesis ; Wolffian duct ; Planar cell polarity ; Male infertility
- 刊名：Developmental Biology
- 出版年：2016
- 出版时间：15 April 2016
- 年：2016
- 卷：412
- 期：2
- 页码：219-233
- 全文大小：18284 K
文摘
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Planar cell polarity and cell rearrangements drive Wolffian duct morphogenesis.
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PTK7 regulates PCP and unique cell rearrangements necessary for convergent extension.
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Polarized activity of myosin underlies convergent extension cell rearrangements.
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Cell division orientation along the ductal axis is random, and not regulated by PTK7.
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PTK7 maintains proper WD morphogenesis, which is necessary for sperm maturation.