PTX3, a humoral pattern recognition molecule at the interface between microbe and matrix recognition
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- 作者：Cecilia Garlanda1 ; Sebastien Jaillon1 ; Andrea Doni1 ; Barbara Bottazzi1 ; Alberto Mantovani1 ; 2 ; alberto.mantovani@humanitasresearch.it" class="auth_mail" title="E-mail the corresponding author
- 刊名：Current Opinion in Immunology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：38
- 期：Complete
- 页码：39-44
- 全文大小：560 K
文摘
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PTX3 acts as an extrinsic oncosuppressor gene.
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PTX3 tunes complement-mediated, macrophage-sustained, tumor promoting inflammation.
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An acidic pH sets the PTX3 molecule in a tissue repair mode.
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Matrix and microbial recognition are related functions in evolution.