An efficient dual-loaded multifunctional nanocarrier for combined photothermal and photodynamic therapy based on copper sulfide and chlorin e6

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• 作者：Xiaoxiao Tan ; Xiaojuan Pang ; Mingzhu Lei ; Man Ma ; Fang Guo ; Jinping Wang ; Meng Yu ; Fengping Tan ; Nan Li ; ^{linan19850115@163.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Chlorin e6 (PubChem CID ; 5479494) ; Copper chloride (PubChem CID ; 24014) ; Sodium sulfide hydrate (PubChem CID ; 73972) ; 1 ; 2-Dialmitoyl-sn-glycero-3-phosphocholine (PubChem CID ; 452110) ; 1 ; 2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (PubChem CID ; 406952) ; Cholesterol (PubChem CID ; 5997)
• 刊名：International Journal of Pharmaceutics
• 出版年：2016
• 出版时间：30 April 2016
• 年：2016
• 卷：503
• 期：1-2
• 页码：220-228
• 全文大小：2807 K

文摘

The therapeutic effectiveness of photodynamic therapy (PDT) was hampered by the poor water solubility and instability in physiological conditions of the photosensitizers. Here, we designed folate conjugated thermosensitive liposomes (TSL) as the nanocarrier to improve the solubility, stability and biocompatibility of photosensitizer Chlorin e6 (Ce6). Based on the photothermal effect, we combined copper sulfide (CuS) as the photothermal agent to realize heat-triggered Ce6 release as well as synergistic effect of photothermal and photodynamic therapy. In vitro MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay showed that Ce6-CuS-TSL had low dark toxicity, while performed excellent phototoxicity under the combined 660 and 808 nm laser irradiation compared to any single laser irradiation alone. Moreover, in vivo combination therapy study revealed that Ce6-CuS-TSL inhibited tumor growth to a great extent without evident side effect under the laser irradiation. All detailed evidence demonstrated a considerable potential of Ce6-CuS-TSL for synergistic cancer treatment.