Study on material base and action mechanism of compound Danshen dripping pills for treatment of atherosclerosis based on modularity analysis

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• 作者：Wei Zhou^a ; ^b ; ^c ; Wen-Feng Yuan^a ; ^b ; ^c ; Chao Chen^a ; ^b ; ^c ; ^{gdpuchenchao@163.com" class="auth_mail" title="E-mail the corresponding author} ; Shu-Mei Wang^a ; ^b ; ^c ; Sheng-Wang Liang^a ; ^b ; ^c
• 关键词：TCM ; Traditional Chinese medicine ; DSP ; Compound Danshen dripping pills ; CCI ; compound-compound interaction ; CPI ; compound-protein interaction ; PPI ; protein-protein interaction ; CSN ; contained chemical subnetwork ; PSN ; pharmacological subnetwork ; GSN ; genomic subnetwork ; TCMSP ; the traditional Chinese medicine systems pharmacology database and analysis platform ; PI ; Promiscuity Index ; 2-HN ; 2-layered heterogeneous network ; CPIs ; compound-protein interactions ; GO ; Gene Ontology ; LDL ; low-density
• 刊名：Journal of Ethnopharmacology
• 出版年：2016
• 出版时间：4 December 2016
• 年：2016
• 卷：193
• 期：Complete
• 页码：36-44
• 全文大小：884 K

文摘

Traditional Chinese medicine (TCM) has been widely used in China and its surrounding countries in clinical treatments for centuries-long time. However, due to the complexity of TCM constituents, both action mechanism and material base of TCM remain nearly unknown.

absSec_2">Aim of the study

The present study was designed to uncover the action mechanism and material base of TCM in a low-cost manner.

absSec_3">Materials and methods

Compound Danshen dripping pills (DSP) is a widely used TCM for treatment of atherosclerosis, and was researched here to demonstrate the effectiveness of our method. We constructed a heterogeneous network for DSP, identified the significant network module, and analyzed the primary pharmacological units by performing GO and pathways enrichment analysis.

absSec_4">Results

Two significant network modules were identified from the heterogeneous network of DSP, and three compounds out of four hub nodes in the network were found to intervene in the process of atherosclerosis. Moreover, 13 out of 20 enriched pathways that were ranked in top 10 corresponding to both the two pharmacological units were found to be involved in the process of atherosclerosis.

absSec_5">Conclusions

Quercetin, luteolin and apigenin may be the main active compounds which modulate the signaling pathways, such as metabolism of xenobiotics by cytochrome P450, retinol metabolism, etc. The present method helps reveal the action mechanism and material base of DSP for treatment of atherosclerosis.