Comparison of tetrodotoxin uptake and gene expression in the liver between juvenile and adult tiger pufferfish, Takifugu rubripes
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- 作者：Aya Kiriakea ; Akira Ohtaa ; Emi Sugaa ; Takuya Matsumotob ; Shoichiro Ishizakia ; Yuji Nagashimaa ; yujicd@kaiyodai.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pufferfish Takifugu rubripes ; Tetrodotoxin ; Hepatic accumulation ; Liver tissue culture ; Suppression subtractive hybridization ; Growth stage
- 刊名：Toxicon
- 出版年：2016
- 出版时间：1 March 2016
- 年：2016
- 卷：111
- 期：Complete
- 页码：6-12
- 全文大小：396 K
文摘
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Pufferfish Takifugu rubripes adults accumulate mainly tetrodotoxin (TTX) in liver.
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In contrast, pufferfish juveniles transferred TTX from the liver to the skin.
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However, there was no difference in TTX uptake in liver tissue slices between them.
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Genes expressed differentially in juvenile and adult liver were analyzed by SSH.
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SSH cDNA libraries revealed candidate genes of T. rubripes liver toxification.