Inflammatory immune response by lipopolysaccharide-responsive nucleotide binding oligomerization domain (NOD)-like receptors in the Japanese pufferfish (Takifugu rubripes)
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- 作者：Gouranga Biswasa ; 1 ; Soner Bilenb ; Tomoya Konoc ; Masahiro Sakaic ; Jun-ichi Hikimac ; jhikima@cc.miyazaki-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Inflammatory cytokines ; Inflammasome ; Intracellular PRRs ; NLR ; Japanese pufferfish ; LPS recognition
- 刊名：Developmental & Comparative Immunology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：55
- 期：Complete
- 页码：21-31
- 全文大小：1415 K
文摘
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Thirteen novel Fugu NLR-Cs were newly identified.
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LPS and nigericin caused inflammatory cytokine response by inducing certain NLR-Cs.
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Fugu NLR-C10 and NLR-C12 may be potential inflammasome candidates.
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Ligand LPS is probably sensed by cytosolic PRRs like NLR-Cs in Fugu.