Midlife predictors of Alzheimer's disease

详细信息    查看全文

• 作者：B.B. Bendlin ; C.M. Carlsson ; C.E. Gleason ; S.C. Johnson ; A. Sodhi ; C.L. Gallagher ; L. Puglielli ; C.D. Engelman ; M.L. Ries ; G. Xu ; W. Wharton ; S. Asthana
• 关键词：Alzheimer's disease ; Dementia ; Midlife ; Genes ; Family history ; Estrogen ; Vascular risk ; Education ; MRI
• 刊名：Maturitas
• 出版年：2010
• 出版时间：February 2010
• 年：2010
• 卷：65
• 期：2
• 页码：131-137
• 全文大小：185 K

文摘

Factors contributing to increased risk for Alzheimer's disease (AD) include age, sex, genes, and family history of AD. Several risk factors for AD are endogenous; however, accumulating evidence implicates modifiable risk factors in the pathogenesis of AD. Although the continued task of identifying new genes will be critical to learning more about the disease, several research findings suggest that potentially alterable environmental factors influence genetic contributions, providing targets for disease prevention and treatment. Here, we review midlife risk factors for AD, and address the potential for therapeutic intervention in midlife.