Post-Translational Regulation of CD133 by ATase1/ATase2-Mediated Lysine Acetylation
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- 作者：Anthony B. Mak1 ; 2 ; Mariana Pehar3 ; 1 ; Allison M.L. Nixon1 ; 2 ; Rashida A. Williams1 ; 2 ; Andrea C. Uetrecht1 ; 2 ; Luigi Puglielli3 ; 4 ; Jason Moffat1 ; 2 ; j.moffat@utoronto.ca" class="auth_mail
- 关键词：CSC ; cancer stem cell ; ER ; endoplasmic reticulum ; ERGIC ; ER Golgi intermediate compartment ; IP-MS ; immunoprecipitation followed with tandem mass spectrometry ; MYTH ; membrane yeast two-hybrid ; shRNA ; short-hairpin RNA ; FACS ; fluorescent activated cell sorting ; BACE1 ; 尾-site APP cleaving enzyme 1
- 刊名：Journal of Molecular Biology
- 出版年：29 May 2014
- 年：2014
- 卷：426
- 期：11
- 页码：2175-2182
- 全文大小：1012 K
文摘
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CD133 marks cancer progenitor cells and has a role in cancer progression.
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ATase1/ATase2 regulates CD133 expression and trafficking by acetylating lysine residues positioned on the first extracellular loop of CD133.
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ATase1/ATase2-mediated lysine acetylation is a form of CD133 protein regulation.
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CD133 regulation and function can be targeted by inhibiting ATase1 or ATase2.