Physical interaction between the MAPK Slt2 of the PKC1-MAPK pathway and Grx3/Grx4 glutaredoxins is required for the oxidative stress response in budding yeast

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• 作者：Nuria Pujol-Carrion ; Maria Angeles de la Torre-Ruiz ; ^{madelatorre@cmb.udl.cat}
• 关键词：Signalling ; Glutaredoxins ; MAPK ; Oxidative stress ; PKC1 pathway ; Budding yeast ; Iron ; Cell survival
• 刊名：Free Radical Biology and Medicine
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：103
• 期：Complete
• 页码：107-120
• 全文大小：2477 K
• 卷排序：103

文摘

The MAPK Slt2 of budding yeast forms a complex with Grx3/Grx4 monothiol glutaredoxins. Clusters iron-sulphur and Cysteine residues play a role in Slt2/Grx3/Grx4 interaction. Slt2/Grx3/Grx4 complex is required for the response to oxidative stress. Slt2 dimer formation increases upon oxidative treatment and requires iron. Grx4 regulates Slt2 activation in response to oxidative stress.