E. coli CNF1 toxin: a two-in-one system for host-cell invasion

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• 作者：Luce L ; raud ; Cé ; line Pulcini ; Pierre Gounon ; Gilles Flatau ; Patrice Boquet ; Emmanuel Lemichez
• 关键词：Escherichia coli ; CNFs ; Rho GTPases ; deamidation ; ubiquitylation ; proteasome
• 刊名：International Journal of Medical Microbiology
• 出版年：2004
• 出版时间：2004
• 年：2004
• 卷：293
• 期：7-8
• 页码：513-518
• 全文大小：81 K

文摘

The cytotoxic necrotizing factor-1 (CNF1), a bacterial toxin of uropathogenic bacteria (UPEC), hijacks cellular Rho proteins of the Ras GTPase super-family. Recently, we have made three important findings. First, we have established that, following Rho protein activation by deamidation, these cellular proteins are ubiquitylated and degraded by the proteasome. Second, the low level of activated Rho proteins which results from the dual molecular mechanism of action of CNF1 (Rho protein activation followed by their degradation), confers high invasive properties to UPECs. Finally, we have reported that ubiquitylation and degradation of Rac is lost in HEp-2 carcinoma cells, thereby suggesting a possible link between Rho protein ubiquitylation and tumor progression.