Effects of casein, whey and soy proteins on volumetric bone density and bone strength in immunocompromised piglets

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• 作者：Alicja Z. Budek ; Charlotte R. Bjornvad ; Christian Mø ; lgaard ; Susanne Bü ; gel ; Mogens Vestergaard ; Pasi Pulkkinen ; Kim F. Michaelsen ; Per T. Sangild
• 关键词：BMD ; Dietary protein ; Immunocompromised piglets ; pQCT
• 刊名：e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism
• 出版年：2007
• 出版时间：June 2007
• 年：2007
• 卷：2
• 期：3
• 页码：57-62
• 全文大小：186 K

文摘

Bone-promoting effect of different proteins in early life, under immunocompromised conditions, is unknown. We investigated effects of milk- and plant-derived proteins on bone development in immunocompromised piglets.

Methods

Newborn, colostrum-deprived piglets were assigned to a formula based on either casein (n=11), whey (n=11) or soy (n=10) as the protein source (each 55 g/L), and equal amounts of fat, carbohydrates, calcium and phosphorus.

Results & Conclusion

Despite efforts to sustain immuno-protection (sow serum and antibiotic injections), some piglets became sick and were early euthanised. After 6 days, bone density (peripheral quantitative computed tomography), bone mechanical strength (three-point bending test) and serum insulin-like growth factor-I (sIGF-I) (immunoassay) were measured in the surviving piglets (casein n=5, whey n=9, soy n=5).

Results

Baseline body weight was not significantly different between the groups and between early euthanised and surviving piglets. After 6 days, all piglets showed depressed growth and low sIGF-I levels. At trabecular sites, whey reduced bone mineral density compared with casein and soy (P0.01), and reduced mineral content compared with casein (P0.01). Whey decreased cortical thickness and bone strength compared with casein (P0.04).

Conclusion

Despite immunocompromised conditions, casein and soy protein may promote a better bone development in colostrum-deprived piglets.