The effect of fatty acid positioning in dietary triacylglycerols and intake of long-chain n-3 polyunsaturated fatty acids on bone mineral accretion in growing piglets

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• 作者：Anders D. Andersen ; Stine E. Ludvig ; Camilla T. Damsgaard ; Pasi Pulkkinen ; Mikko Finnil? ; Huiling Mu ; Thomas Thymann ; Kim F. Michaelsen ; Christian M?lgaard ; Lotte Lauritzen
• 关键词：BA ; bone area ; BMC ; bone mineral content ; BMD ; bone mineral density ; CONT ; control ; DHA ; docosahexaenoic acid ; DEXA ; dual-energy x-ray absorptiometry ; FO ; fish oil ; HMFS ; human milk fat substitute ; LCPUFA ; long-chain polyunsaturated fatty acid ; NEFA ; non-
• 刊名：Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)
• 出版年：2013
• 出版时间：September, 2013
• 年：2013
• 卷：89
• 期：4
• 页码：235-240
• 全文大小：342 K

文摘

Long-chain n-3 PUFA (LCPUFA) and palmitate (16:0) positioning in the triacylglycerol (TAG) of infant formula may affect calcium-uptake which could affect bone health. We investigated if a human milk fat substitute (HMFS) with a modified TAG structure holding 16:0 predominantly in the sn-2-position compared with a control (CONT) and if increasing n-3LCPUFA intake giving fish oil (FO) compared with sunflower oil (SO) would affect bone parameters in piglets in two sets of controlled 14d-interventions (n=12/group). We assessed this by dual-energy x-ray absorptiometry, and ex vivo peripheral quantitative computed tomography and mechanical strength. Bone mineral content (BMC) was higher in the FO compared to the SO-group (p=0.03). Despite similar weight gain in HMFS- and CONT-groups, body fat accumulation was higher with HMFS (p<0.001), and BMC, bone area (BA) and cortical BA in femur were lower (p=0.002, p=0.005, and p=0.02, respectively), indicating importance of both n-3LCPUFA and 16:0 TAG-positioning in infant formulas.