Association between pulsatile blood pressure and cognitive performance among older adults: Insight from the National Health and Nutrition Examination Survey 1999-2002

详细信息    查看全文

• 作者：Wesley K. Lefferts ; ^{wleffert@syr.edu" class="auth_mail" title="E-mail the corresponding author} ; Kevin S. Heffernan ; Tiago V. Barreira
• 关键词：Pulsatile blood pressure ; Cognition ; NHANES
• 刊名：International Journal of Cardiology
• 出版年：2016
• 出版时间：15 November 2016
• 年：2016
• 卷：223
• 期：Complete
• 页码：981-984
• 全文大小：170 K

文摘

High blood pressure (BP) may be associated with impaired cognitive function. BP is comprised of a steady (mean arterial pressure; MAP) and pulsatile (pulse pressure; PP) component. The purpose of this study was to examine the relationship between steady and pulsatile BP and cognition among adults ≥ 60 years old.

Methods

2058 adults age 60–85 years from the 1999–2002 NHANES were used in this analysis. MAP and PP were calculated from brachial BP as 1/3 systolic + 2/3 diastolic BP, and systolic – diastolic BP, respectively. Cognition was assessed using the digit-symbol substitution test (DSST).

Results

Unadjusted multiple regression revealed although PP independently predicted DSST score (β = − 0.21, p < 0.05), MAP was only predictive when entered simultaneously with PP (β = 0.06, p < 0.05). Further adjustments for sociodemographics and medical history significantly improved prediction of DSST score (∆ R² = 0.37, p < 0.05), and removed the association between MAP and DSST score, although PP remained a significant predictor (β = − 0.07, p < 0.05).

Conclusions

PP, but not MAP, was significantly and inversely related to cognitive function among a representative sample of adults aged ≥ 60 years after controlling for sociodemographic information and medical history.