mTORC1 alters the expression of glycolytic genes by regulating KPNA2 abundances
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- 作者：Xianwei Chena ; b ; chenxw@big.ac.cn" class="auth_mail" title="E-mail the corresponding author ; Yinghui Zhua ; b ; yhzhu@big.ac.cn" class="auth_mail" title="E-mail the corresponding author ; Zhaohui Wanga ; wangzhaohui85@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Huishan Zhuc ; huishanzhu33@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Qingfei Pana ; b ; panqf@big.ac.cn" class="auth_mail" title="E-mail the corresponding author ; Siyuan Sua ; b ; susy@big.ac.cn" class="auth_mail" title="E-mail the corresponding author ; Yusheng Dongc ; dongysh@genomics.cn" class="auth_mail" title="E-mail the corresponding author ; Li Lid ; rene_ll@126.com" class="auth_mail" title="E-mail the corresponding author ; Hongbing Zhangd ; hbzhang@ibms.pumc.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Lin Wua ; b ; wul@big.ac.cn" class="auth_mail" title="E-mail the corresponding author ; Xiaomin Loua ; b ; louxm@big.ac.cn" class="auth_mail" title="E-mail the corresponding author ; Siqi Liua ; b ; siqiliu@big.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：mTORC1 ; Rapamycin ; Proteomics ; KPNA2 ; HIF1α ; Glycolysis
- 刊名：Journal of Proteomics
- 出版年：2016
- 出版时间：16 March 2016
- 年：2016
- 卷：136
- 期：Complete
- 页码：13-24
- 全文大小：1543 K
文摘
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mTORC1 activation upregulated the proteins in protein nuclear import and glycolysis.
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mTORC1 positively regulated KPNA2 expression in multiple cell lines.
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S6K1 and 4E-BP1 did not participate in KPNA2 regulation by mTORC1.
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mTORC1 regulated KPNA2 at transcriptional level.
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mTORC1 regulated glycolysis genes through controlling KPNA2 expression.