Part II of the cutaneous deposition disorders focuses on cutaneous calcification and ossification, alkaptonuria and ochronosis, and gout. These disorders have in common the deposition of materials in the dermis or subcutis and often involve metabolic defects in hormonal and enzymatic regulation. The pathogenesis, clinical findings, and treatment of these diseases are discussed. Both the histologic and ultrastructural findings are reviewed. (J Am Acad Dermatol 1998;39:527-44.)
Learning Objective: After reading this review, the practitioner should be familiar with both the cutaneous and systemic manifestations of these disorders.