Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): a randomised, open-label, multicentre, phase 3 trial

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• 作者：Dr José ; Baselga ; MD^a ; ^b ; ^{jbaselga@partners.org} ; Ian Bradbury ; PhD^c ; ^d ; Holger Eidtmann ; MD^e ; Serena Di Cosimo ; MD^b ; ^f ; ^h ; Evandro de Azambuja ; MDⁱ ; Claudia Aura ; MD^g ; Henry Gó ; mez ; MD^l ; Phuong Dinh ; MD^j ; Karine Fauria ; PhD^b ; Veerle Van Dooren ; MScⁱ ; Gursel Aktan ; MD^m ; Aron Goldhirsch ; MDⁿ ; ^o ; Tsai-Wang Chang ; MD^p ; Zsolt Horvá ; th ; MD^q ; Maria Coccia-Portugal ; MD^r ; Julien Domont ; MD^s ; Ling-Min Tseng ; MD^t ; Georg Kunz ; MD^u ; Joo Hyuk Sohn ; MD^v ; Vladimir Semiglazov ; MD^w ; Guillermo Lerzo ; MD^x ; Marketa Palacova ; MD^y ; Volodymyr Probachai ; MD^z ; Lajos Pusztai ; DPhil^aa ; Michael Untch ; PhD^ab ; Richard D Gelber ; PhD^ac ; ^ad ; Martine Piccart-Gebhart ; PhD^k ; on behalf of the NeoALTTO Study Team
• 刊名：The Lancet
• 出版年：2012
• 出版时间：18-24 February 2012
• 年：2012
• 卷：379
• 期：9816
• 页码：633-640
• 全文大小：320 K

文摘

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Summary

Background

The anti-HER2 monoclonal antibody trastuzumab and the tyrosine kinase inhibitor lapatinib have complementary mechanisms of action and synergistic antitumour activity in models of HER2-overexpressing breast cancer. We argue that the two anti-HER2 agents given together would be better than single-agent therapy.

Methods

In this parallel groups, randomised, open-label, phase 3 study undertaken between Jan 5, 2008, and May 27, 2010, women from 23 countries with HER2-positive primary breast cancer with tumours greater than 2 cm in diameter were randomly assigned to oral lapatinib (1500 mg), intravenous trastuzumab (loading dose 4 mg/m², subsequent doses 2 mg/kg), or lapatinib (1000 mg) plus trastuzumab. Treatment allocation was by stratified, permuted blocks randomisation, with four stratification factors. Anti-HER2 therapy alone was given for the first 6 weeks; weekly paclitaxel (80 mg/m²) was then added to the regimen for a further 12 weeks, before definitive surgery was undertaken. After surgery, patients received adjuvant chemotherapy followed by the same targeted therapy as in the neoadjuvant phase to 52 weeks. The primary endpoint was the rate of pathological complete response (pCR), analysed by intention to treat. This trial is registered with , .

Findings

154 patients received lapatinib, 149 trastuzumab, and 152 the combination. pCR rate was significantly higher in the group given lapatinib and trastuzumab (78 of 152 patients [51¡¤3 % ; 95 % CI 43¡¤1-59¡¤5]) than in the group given trastuzumab alone (44 of 149 patients [29¡¤5 % ; 22¡¤4-37¡¤5]; difference 21¡¤1 % , 9¡¤1-34¡¤2, p=0¡¤0001). We recorded no significant difference in pCR between the lapatinib (38 of 154 patients [24¡¤7 % , 18¡¤1-32¡¤3]) and the trastuzumab (difference ?¡¤8 % , ?7¡¤6 to 8¡¤2, p=0¡¤34) groups. No major cardiac dysfunctions occurred. Frequency of grade 3 diarrhoea was higher with lapatinib (36 patients [23¡¤4 % ]) and lapatinib plus trastuzumab (32 [21¡¤1 % ]) than with trastuzumab (three [2¡¤0 % ]). Similarly, grade 3 liver-enzyme alterations were more frequent with lapatinib (27 [17¡¤5 % ]) and lapatinib plus trastuzumab (15 [9¡¤9 % ]) than with trastuzumab (11 [7¡¤4 % ]).

Interpretation

Dual inhibition of HER2 might be a valid approach to treatment of HER2-positive breast cancer in the neoadjuvant setting.

Funding

GlaxoSmithKline.