The kinetic and mechanistic picture of oxidation of pregabalin with alkaline chloramine-T have been clarified.
The catalytic efficiency of the catalysts used follows the order: (RuCl3 + OsO4) > OsO4 > RuCl3.
The most noteworthy is the significant synergistic effect of 71-fold in case of (RuCl3 + OsO4) catalyst.