Synthesis and biological evaluation of salicylic acid conjugated isoxazoline analogues on immune cell proliferation and angiogenesis
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- 作者：Naveen Puttaswamya ; b ; G.S. Pavan Kumarc ; Mohammed Al-Ghorbania ; V. Vigneshwaranc ; B.T. Prabhakarc ; Shaukath Ara Khanuma ; shaukathara@yahoo.co.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：Salicylic acid ; Isoxazaoline ; Mitogenecity ; Lymphocytes ; IL-2
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：23 May 2016
- 年：2016
- 卷：114
- 期：Complete
- 页码：153-161
- 全文大小：927 K
文摘
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Synthesis of salicylic acid fused isoxazoline analogues 8a-j via 1, 3-dipolar cycloaddition.
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These synthesized compounds were characterized by spectral and analytical techniques.
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Further, compounds (8a-j) were screened for biological applications.
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Compound 8e showed a potent proliferative response on both human and murine lymphocytes.