- 作者：Sarita V. Mello ; sarita_mello@colpal.com ; Evangelia Arvanitidou ; Mark Vandeven
- 关键词：Mouthwash ; Tooth sensitivity ; Arginine ; PVM/MA copolymer ; Tubule occlusion ; Dentine
- 刊名：Journal of Dentistry
- 出版年：2013
- 出版时间：1 March, 2013
- 年：2013
- 卷：41
- 期：supp_S1
- 页码：S20-S25
- 全文大小：430 K
Objective
To investigate the ability of a novel mouthwash comprised of 0.8 % arginine, PVM/MA copolymer, pyrophosphates, and 0.05 % sodium fluoride in an alcohol-free base (Pro-Argin? Mouthwash Technology) to reduce dentine permeability.Methods
Hydraulic conductance was used to assess the dentine permeability effects of the arginine mouthwash. Aqueous solutions containing arginine and PVM/MA copolymer were studied in the initial stage of the method development. The acid resistance was tested with a cola drink challenge. Finally, a blinded study was carried out to determine the occlusion of the arginine mouthwash in comparison to a negative control mouthwash.
Results
Dentine discs treated with the arginine mouthwash showed an average fluid reduction of 42 % , which was statistically, significantly better than the fluid reduction for the negative control mouthwash. In addition, experiments using simple solutions of arginine and PVM/MA copolymer, alone and in combination, demonstrated that the combination of the two was required to provide a relevant occlusion benefit. Finally, the occlusion provided by the arginine mouthwash was maintained after exposure to an acid challenge.
Conclusion
The exclusive combination of ingredients in the arginine mouthwash has been proven to be efficacious in decreasing dentine fluid flow as measured by hydraulic conductance. The new mouthwash works by occlusion, due to the unique combination of arginine, PVM/MA copolymer and pyrophosphates.