Role of 14-3-3 sigma in over-expression of P-gp by rifampin and paclitaxel stimulation through interaction with PXR

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• 作者：So Won Kim^a ; ^b ; ¹ ; ^{kerorosw@gmail.com} ; Md. Hasanuzzaman^c ; ^e ; ¹ ; Munju Cho^c ; Nam Hyun Kim^a ; Hye-Young Choi^a ; Jung Woo Han^f ; Hyun June Park^g ; Ji Won Oh^h ; ⁱ ; Jae-Gook Shin^c ; ^d ; ^{phshinjg@gmail.com}
• 关键词：14-3-3 sigma ; Pregnane X Receptor (PXR) ; Multidrug Resistance Protein 1 (MDR1) ; Hsp90 beta ; Rifampin ; Paclitaxel
• 刊名：Cellular Signalling
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：31
• 期：Complete
• 页码：124-134
• 全文大小：1100 K
• 卷排序：31

文摘

The signaling pathway inducing P-gp overexpression by rifampin and paclitaxel is proposed. CK2 phosphorylates Hsp90β, and Hsp90β binds to PXR in the cytoplasm. 14-3-3σ is also binds to PXR in the cytoplasm by rifampin and paclitaxel stimulation. PXR stability is increased in cytoplasm after binding with Hsp90β and 14-3-3σ, and translocated into nucleus to induce MDR1.