Ebola Virus Glycoprotein with Increased Infectivity Dominated the 2013-2016 Epidemic
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- 作者：William E. Diehl1 ; 9 ; Aaron E. Lin2 ; 3 ; 9 ; Nathan D. Grubaugh4 ; 9 ; Luiz Max Carvalho5 ; 9 ; Kyusik Kim1 ; Pyae Phyo Kyawe6 ; Sean M. McCauley1 ; Elisa Donnard1 ; 7 ; Alper Kucukural1 ; 7 ; Patrick McDonel1 ; 7 ; Stephen F. Schaffner2 ; 3 ; Manuel Garber1 ; 7 ; Andrew Rambaut5 ; Kristian G. Andersen2 ; 4 ; 8 ; andersen@scripps.edu" class="auth_mail" title="E-mail the corresponding author ; Pardis C. Sabeti2 ; 3 ; pardis@broadinstitute.org" class="auth_mail" title="E-mail the corresponding author ; Jeremy Luban1 ; 10 ; jeremy.luban@umassmed.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ebola virus ; epidemic ; mutation ; NPC1 ; glycoprotein ; outbreak ; RNA virus ; Filovirus ; adaptation ; infection
- 刊名：Cell
- 出版年：2016
- 出版时间：3 November 2016
- 年：2016
- 卷：167
- 期：4
- 页码：1088-1098.e6
- 全文大小：3397 K
文摘
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Ebola glycoprotein mutant GP-A82V arose early and dominated the West African epidemic
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GP-A82V infects human cells more efficiently than does the ancestral glycoprotein
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The increased infectivity of GP-A82V is specific for primate cells
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GP-A82V was weakly associated with increased mortality during the epidemic