Ganglioside GQ1b induces dopamine release through the activation of Pyk2
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- 作者：Zhao Zhanga ; Shi-Feng Chub ; Zheng Moua ; Yan Gaoa ; Zhen-Zhen Wanga ; Gui-Ning Weic ; Nai-Hong Chena ; chennh@imm.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pyk2 ; GQ1b ; Dopamine ; PC12 ; MAPK/ERK ; Synapsin I ; F-actin
- 刊名：Molecular and Cellular Neuroscience
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：71
- 期：Complete
- 页码：102-113
- 全文大小：1680 K
文摘
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Ganglioside GQ1b enhances asynchronous dopamine release from PC12 cells and rat striatal slices.
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Intracellular Ca2 + is a major factor in GQ1b induced DA release.
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Pyk2 inhibition abolishes GQ1b induced DA release.
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Autophosphorylation of Pyk2 is essential for GQ1b-evoked DA release.
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Pyk2 intermediates GQ1b induced activation of ERK1/2 and DA release.
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Phosphorylation of Synapsin I and depolymerization of actin are the main causes of GQ1b induced DA release.