Low density lipoprotein receptor-related protein 1 mediated endocytosis of β1-integrin influences cell adhesion and cell migration
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- 作者：Verena K. Rabieja ; Thorsten Pflanznera ; Timo Wagnera ; Kristina Goetzeb ; Steffen E. Storcka ; Johannes A. Eblec ; Sascha Weggend ; Wolfgang Mueller-Klieserb ; Claus U. Pietrzika ; pietrzik@uni-mainz.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：LRP1 ; low density lipoprotein receptor related-protein 1 ; Snx17 ; Sorting nexin 17 ; PSD95 ; postsynaptic density protein 95 ; Dab-2 ; disabled homolog 2 ; ECM ; extracellular matrix ; RMS ; rostral migratory stream ; BrdU ; 5-bromo-2-deoxyuridine ; CPZ ; chlorpromazine ; FA ; focal adhesion ; FAK ; focal adhesion kinase ; pFAK Y397 ; focal adhesion kinase phosphorylated at tyrosine 397 ; MMP ; matrix metalloproteases ; SVZ ; subventricular zone ; Pyk2 ; proline-rich tyrosine kinase 2 ; APP ; amyloid precursor protein ; Ra
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：340
- 期：1
- 页码：102-115
- 全文大小：6052 K
文摘
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LRP1 mediates β1-integrin interaction through its NPxY2 motif.
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LRP1 β1-integrin interaction influences β1-integrin internalization.
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LRP1 acts as a potential regulator of cell migration and adhesion.