Notch2 signaling promotes osteoclast resorption via activation of PYK2
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- 作者：Won Jong Jina ; Bongjun Kima ; Jung-Wook Kima ; Hong-Hee Kima ; Hyunil Hab ; hyunil74@kiom.re.kr" class="auth_mail" title="E-mail the corresponding author ; Zang Hee Leea ; zang1959@snu.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：DBZ ; dibenzazepine ; NFATc1 ; nuclear factor of activated T cells ; cytoplasmic 1 ; PYK2 ; proline-rich tyrosine kinase 2 ; NICD2 ; Notch intracellular domain 2 ; IL-1 ; interleukin 1
- 刊名：Cellular Signalling
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：28
- 期：5
- 页码：357-365
- 全文大小：3816 K
文摘
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Overexpression of CA-NFATc1 does not rescue the resorption defect caused by the Notch signaling inhibitor DBZ.
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DBZ suppresses both activation of PYK2 and interaction of PYK2 with c-Src.
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NICD2 promotes PYK2 autophosphorylation, PYK2/c-Src interaction, and microtubule acetylation.
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NICD2 is necessary for normal osteoclast spreading, actin ring formation, and resorption activity.