Novel pyrazolo[3,4-d]pyrimidine with 4-(1H-benzimidazol-2-yl)-phenylamine as broad spectrum anticancer agents: Synthesis, cell based assay, topoisomerase inhibition, DNA intercalation and bovine serum albumin studies
文摘
A Series of pyrazolo[3,4-d]pyrimidine-benzimidazole conjugate has been synthesized. Compounds were evaluated in vitro for 60 human cancer cell lines. Four compounds showed excellent antiproliferative activities. Calf thymus-DNA interactions with compounds have been studied. Compounds have also been investigated for bovine serum albumin-binding activity.