Synthesis of New Azino Fused Benzimidazolium Salts. A New Family of DNA Intercalating Agents. I

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• 作者：Pastor ; Joaquí ; n ; Siró ; Jorge ; Garcí ; a-Naví ; o ; José ; L. ; et. al.
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：1995
• 出版时间：December 21, 1995
• 年：1995
• 卷：5
• 期：2
• 页码：3043-3048
• 全文大小：345 K

文摘

A series of new pyrido[1,2-a]- and pyridazino[1,6-a]benzimidazolium salts have been synthesized from readily available 1,3-disubstituted 2-alkylbenzimidazolium salts. Their affinity to DNA and in vitro cytotoxicity versus HT-29 have been tested. The initial results show that the title compounds are a new family of intercalating agents.