Antioxidant activity and interaction with DNA and albumins of zinc-tolfenamato complexes. Crystal structure of [Zn(tolfenamato)₂(2,2鈥?dipyridylketoneoxime)₂]

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• 作者：Alketa Tarushi^a ; Xanthippi Totta^a ; Athanasios Papadopoulos^b ; Jakob Kljun^c ; ^d ; Iztok Turel^d ; Dimitris P. Kessissoglou^a ; George Psomas^a ; ^{gepsomas@chem.auth.gr" class="auth_mail}
• 关键词：Zinc(II) complexes ; Tolfenamic acid ; Interaction with calf-thymus DNA ; Interaction with serum albumins ; Antioxidant activity
• 刊名：European Journal of Medicinal Chemistry
• 出版年：3 March, 2014
• 年：2014
• 卷：74
• 期：Complete
• 页码：187-198
• 全文大小：1146 K

文摘

The zinc(II) complex of the non-steroidal anti-inflammatory drug tolfenamic acid (=Htolf) in the presence of 2,2鈥?dipyridylketone oxime (=Hpko) as a N,N鈥?donor heterocyclic ligand, [Zn(tolf-O)₂(Hpko-N,N鈥?₂]路MeOH (=1路MeOH), has been synthesized and characterized by physicochemical techniques including X-ray crystallography. The complex exhibits good binding affinity to human or bovine serum albumin with high binding constant values. Complex 1 and previously reported Zn-tolfenamato complexes were tested for their free radical scavenging activity and in聽vitro inhibitory activity against soybean lipoxygenase and exhibited significant activity with [Zn(tolf)₂(1,10-phenantroline)] being the most active compound. The complexes interact with calf-thymus (CT) DNA via intercalation, and can displace the DNA-bound ethidium bromide with 1 exhibiting the highest binding constant to CT DNA.