Dihydroorotate dehydrogenase: A drug target for the development of antimalarials

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• 作者：Anju Singh ; Mudasir Maqbool ; Mohammad Mobashir ; Nasimul Hoda ; ^{nhoda@jmi.ac.in}
• 关键词：Malaria ; Dihydroorotate dehydrogenase (DHODH) ; Pyrimidine biosynthesis ; Plasmodium parasite ; Drug resistance
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：125
• 期：Complete
• 页码：640-651
• 全文大小：1951 K
• 卷排序：125

文摘

Malaria is one of the most life threatening neglected disease with no complete cure. Plasmodium parasite solely and wholly depends on pyrimidine biosynthesis for its survival. Dihydroorotate dehydrogenase has key importance in pyrimidine biosynthesis of the parasite. Inhibition of DHODH may provide a complete cure to malaria.