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• 作者：Gulevskaya ; Anna V. ; Besedin ; Denis V. ; Pozharskii ; Alexander F. ; Starikova ; Zoya A.
• 刊名：Tetrahedron Letters
• 出版年：2001
• 出版时间：August 20, 2001
• 年：2001
• 卷：42
• 期：34
• 页码：5981-5983
• 全文大小：90.8 K

文摘

6,8-Dimethylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-dione has been shown to react with some secondary amines in the presence of an oxidant to produce 6,8-dimethylpyrrolo[2′,3′;3,4]pyridazino[6,5-d]pyrimidine-7,9(6H,8H)-dione derivatives. The reaction represents a new method of pyrrole-ring annulation to an azine nucleus via a tandem S_N^H–S_N^H process.