γδ T cells account for approximately 5% of CD3⁺ T cells in the blood and frequently express a Vγ9Vδ2 T-cell receptor

Vγ9Vδ2 T cells recognize pyrophosphate molecules that are produced by bacteria but also by many tumor cells

Vγ9Vδ2 T cells kill a broad variety of different tumor cells in an HLA-nonrestricted fashion

Vγ9Vδ2 T cell activation and expansion can be manipulated pharmacologically, e.g. by nitrogen-containing bisphosphonates

Vγ9Vδ2 T cells are attractive candiates for cellular immuotherapy