Improved binding affinities of pyrrolidine derivatives as Mcl-1 inhibitors by modifying amino acid side chains

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• 作者：Yichao Wan ; Tingting Liu ; Xiaoxian Li ; Chen Chen ; Hao Fang ; ^{haofangcn@sdu.edu.cn}
• 关键词：Bcl-2 ; Mcl-1 ; Cancer ; Pyrrolidine ; Target
• 刊名：Bioorganic & Medicinal Chemistry
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：25
• 期：1
• 页码：138-152
• 全文大小：970 K
• 卷排序：25

文摘

A series of pyrrolidine derivatives as Mcl-1 inhibitors were synthesized. Some of them exhibited remarkably inhibitory activities for Mcl-1 protein. Compound 40 possessed good anti-proliferative activities against PC-3 cells.