μ-Opposing actions of the κ-opioid receptor
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- 作者：Pan ; Z. Z.
- 关键词：kappa-opiod receptor ; mu-opiod receptor ; analgesia ; tolerance ; reward ; memory ; CI977 ; (5r)-(5α ; 7α ; 8β ; )-N-methyl-N-(7-[1-pyrrolidinyl]-1-oxaspiro[4 ; 5]dec-8-yl)-4-benzofuranacetamide monohydrochloride ; U50488 ; trans-(± ; )-3 ; 4-dichloro-N-m
- 刊名：Trends in Pharmacological Sciences
- 出版年：1998
- 出版时间：March 1, 1998
- 年：1998
- 卷：19
- 期：3
- 页码：94-98
- 全文大小：163 K
文摘
Pharmacological studies and recent research using genetic approaches have indicated that most actions of exogenous opioids, such as morphine, are mediated through the μ-opioid receptor. By contrast, the function of the κ-opioid receptor in opioid actions largely remains unclear. In this article, Zhizhong Z. Pan discusses the accumulating evidence that activation of the κ-receptor antagonizes various μ-receptor-mediated actions in the brain, including analgesia, tolerance, reward and memory processes. The neural mechanism for this potentially ubiquitous μ-opposing function of the κ-receptor is believed to involve distinct locations of the two opioid receptors on physiologically different cell types in local neuronal networks that are implicated in an opioid action.