Copper-mediated selective aerobic oxidative C3-cyanation of indoles with DMF

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• 作者：Jing Xiao^a ; Qiang Li^a ; Tieqiao Chen^a ; ^{chentieqiao@hnu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Li-Biao Han^b ; ^{libiao-han@aist.go.jp" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Indole ; C&ndash ; H cyanation ; Aerobic oxidation ; Copper ; DMF
• 刊名：Tetrahedron Letters
• 出版年：2015
• 出版时间：21 October 2015
• 年：2015
• 卷：56
• 期：43
• 页码：5937-5940
• 全文大小：1007 K

文摘

Under an oxygen atmosphere, the copper-mediated direct C3-cyanation of indole C–H bonds, using cheap and safe DMF as a CN source, took place selectively to produce the corresponding C3-cyanoindoles in good yields. A possible mechanism for this selective cyanation was proposed.