Investigations on the Flat-Detector Computed Tomography−Based CBV Map Acquisition Using a Left Ventricle Contrast Media Injection Protocol

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• 作者：Song Chaoyan¹ ; ² ; Zhang Qiang² ; ^{vivien-sun1226@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Sun Qi³ ; Zhang Hao² ; Shan Tonghui² ; Pan Wenlong² ; Wang Mei² ; Han Jingfeng³ ; Deuerling-Zheng Yu⁴ ; Xu Ruxiang¹ ; ² ; ^{xuruxiang_bjjz@hotmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Cerebral blood volume ; Color-coded quantitative digital subtraction angiography ; Flat-detector computed tomography ; Left ventricle ; Perfusion symmetry
• 刊名：World Neurosurgery
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：84
• 期：6
• 页码：1629-1635
• 全文大小：4520 K

文摘

Cerebral blood volume (CBV) acquired with the use of flat-detector computed tomography with contrast media (CM) injected at the ascending aorta provides real-time brain functional information with minimized CM usage; however, unexpected asymmetric perfusion is observed for certain patients without cerebral circulatory disorders. This work tested the feasibility of left ventricle (LV) CM injection to achieve symmetric perfusion.

Methods

CBV maps were acquired for 10 patients without perfusion-related cerebral abnormities. Perfusion symmetry was predicted with the use of color-coded quantitative digital subtracted angiography with CM injected at ascending aorta. Time density curves were extracted at bilateral common carotid arties with area under curves calculated. Planes were selected on CBV maps with regions of interest defined covering characteristic regions, where asymmetric perfusion most likely to appear.

Results

No adverse physiological changes were detected for any patient. Non-uniform CM distributions were detected for 4 patients with relative area under curves 0.66 ± 0.03, indicating asymmetric perfusion using ascending aorta injection. With LV injection, all the patients demonstrated good perfusion symmetry with relative CBV 1.03 ± 0.07.

Conclusion

CBV maps acquisition with LV injection offered an approach to acquire immediate brain functional information for patients who are limited by asymmetric perfusion using ascending aorta injection and are sensitive to CM dose.