Vitexin reduces hypoxia-ischemia neonatal brain injury by the inhibition of HIF-1alpha in a rat pup model
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- 作者：Jia-Wei Mina ; Jiang-Jian Hua ; Miao Hea ; Russell M. Sanchezb ; Wen-Xian Huangc ; Yu-Qiang Liua ; Najeeb Bassam Bsoula ; Song Hanc ; Jun Yinc ; Wan-Hong Liud ; Xiao-Hua Hec ; hexiaohua@whu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Bi-Wen Penga ; pengbiwen@whu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Vitexin ; Hypoxia-inducible factor ; Hypoxia&ndash ; ischemia ; Neonatal rat
- 刊名：Neuropharmacology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：99
- 期：Complete
- 页码：38-50
- 全文大小：3963 K
文摘
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Vitexin, a HIF-1α inhibitor, is identified in medicinal plants.
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Vitexin was neuroprotective by decreasing infarct volume at 48 h post-HI.
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Vitexin ameliorated brain edema, BBB disruption and neuronal cell death.
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Vitexin attenuated the increase in HIF-1α and VEGF after HI.
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Vitexin had a long-term effect and improved the neurobehavioral outcomes.