Chemoprotective effects of Ganoderma atrum polysaccharide in cyclophosphamide-induced mice
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- 作者：Qiang Yu ; Shao-Ping Nie ; Jun-Qiao Wang ; Xiao-Zhen Liu ; Peng-Fei Yin ; Dan-Fei Huang ; Wen-Juan Li ; De-Ming Gong ; Ming-Yong Xie
- 关键词：PSG-1 ; Ganoderma atrum polysaccharide ; Cy ; cyclophosphamide ; LH ; levamisole hydrochloride ; NC ; normal control ; MC ; model control ; Ig ; immunoglobulin ; T-AOC ; total antioxidant capacity ; MDA ; malondialdehyde ; CAT ; catalase ; SOD ; superoxidase dismutase ; GSH-Px ; glutathione peroxidise ; WBC ; white blood cell ; RBC ; red blood cell ; NK cell ; natural killer cell ; CTL ; cytotoxic T lymphocyte
- 刊名：International Journal of Biological Macromolecules
- 出版年：March, 2014
- 年：2014
- 卷：64
- 期：Complete
- 页码：395-401
- 全文大小：1013 K
文摘
In this study, the chemoprotective effects of Ganoderma atrum polysaccharide (PSG-1) in cyclophosphamide (Cy) treated mice were investigated. In Cy-treated mice, PSG-1 treatment accelerated recovery dose-dependently of peripheral red blood cells, white blood cells and platelets, enhanced splenic natural killer cell activity and cytotoxic T lymphocyte activity. In addition, PSG-1 elevated CD4+ T lymphocyte counts as well as the CD4+/CD8+ ratio dose-dependently. Furthermore, PSG-1 restored the levels of IL-2, INF-纬, IL-10, IgA, IgM and IgG, as well as hemolysin in the sera. Finally, PSG-1 can also significantly increase the total antioxidant capacity, activities of superoxidase dismutase, catalase and glutathione peroxidase, and decrease the malondialdehyde level in vivo. These findings indicate that PSG-1 plays an important role in the protection against myelosuppression and immunosuppression and oxidative stress in Cy-treated mice and could be a potential immunomodulatory agent.