Small-Molecule Targeting of E3 Ligase Adaptor SPOP in Kidney Cancer
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- 作者：Zhong-Qiang Guo1 ; 3 ; 4 ; 12 ; Tong Zheng2 ; 5 ; 12 ; Baoen Chen2 ; 12 ; Cheng Luo6 ; 12 ; Sisheng Ouyang6 ; 12 ; Shouzhe Gong2 ; Jiafei Li2 ; Liu-Liang Mao7 ; Fulin Lian8 ; Yong Yang9 ; Yue Huang2 ; 5 ; Li Li2 ; Jing Lu10 ; Bidong Zhang5 ; 6 ; Luming Zhou11 ; Hong Ding6 ; Zhiwei Gao9 ; Liqun Zhou3 ; Guoqiang Li1 ; Ran Zhou6 ; Ke Chen1 ; Jingqiu Liu6 ; Yi Wen8 ; Likun Gong10 ; Yuwen Ke1 ; Shang-Dong Yang7 ; Xiao-Bo Qiu11 ; Naixia Zhang8 ; Jin Ren10 ; Dafang Zhong9 ; Cai-Guang Yang2 ; yangcg@simm.ac.cn" class="auth_mail" title="E-mail the corresponding author ; Jiang Liu1 ; liuj@big.ac.cn" class="auth_mail" title="E-mail the corresponding author ; Hualiang Jiang6 ; 13 ; hljiang@simm.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cancer Cell
- 出版年：2016
- 出版时间：12 September 2016
- 年：2016
- 卷：30
- 期：3
- 页码：474-484
- 全文大小：3024 K
文摘
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Computational design and synthetic optimization yield SPOP inhibitors
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SPOP inhibitors suppress oncogenic SPOP-signaling pathways in ccRCC
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SPOP inhibitors induce cell death and prevent tumor progress of ccRCC
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Inhibiting SPOP-substrate interactions may be a potential approach against ccRCC