Bioconcentration, metabolism and alterations of thyroid hormones of Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) in Zebrafish
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- 作者：Tao Xua ; Qiangwei Wangb ; c ; wqiangwei@ihb.ac.cn" class="auth_mail" title="E-mail the corresponding author ; Qipeng Shib ; Qi Fangb ; Yongyong Guob ; Bingsheng Zhoub
- 关键词：TDCPP ; Bioconcentration and metabolism ; Zebrafish ; Thyroid hormones
- 刊名：Environmental Toxicology and Pharmacology
- 出版年：2015
- 出版时间：September 2015
- 年：2015
- 卷：40
- 期：2
- 页码：581-586
- 全文大小：1271 K
文摘
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The bioaccumulation and biotransformation of TDCPP in zebrafish liver was studied.
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High levels of TDCPP and its metabolite BDCPP were found in the zebrafish livers.
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Genes involved in phase I and II metabolism were upregulated after TDCPP exposure.
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Levels of thyroid hormones decreased in female zebrafish after TDCPP exposure.