- 作者：Zhixin Huang ; Qin Yin ; Wen Sun ; Wusheng Zhu ; Yongkun Li ; Wenhua Liu ; Lulu Xiao ; Zuowei Duan ; Qiankun Cai ; Dezhi Liu ; Minmin Ma ; Xinfeng Liu
- 关键词：Cerebral microbleeds ; Adiponectin ; sE-selectin ; Endothelial dysfunction ; Marker ; Ischemic stroke
- 刊名：Journal of the Neurological Sciences
- 出版年：15 November, 2013
- 年：2013
- 卷：334
- 期：1-2
- 页码：83-87
- 全文大小：299 K
Background
Cerebral microbleeds (CMBs) are the important indicators of cerebral small vessel disease. However, it is still unclear whether endothelial dysfunction is involved in CMBs. In this study, we performed a prospective study to investigate the correlation between sE-selectin (soluble E-selectin) or adiponectin and the prevalence of CMBs.Methods
We recruited 133 consecutive patients with first-ever ischemic stroke for this study. Finally, 126 patients were analyzed. The number and presence of CMBs were detected and evaluated on susceptibility-weighted magnetic resonance imaging within two weeks after symptom onset. We assessed the serum levels of adiponectin and sE-selectin for patients.
Results
CMBs were detected in 63 subjects (50%) within 126 patients and more prevalent in mixed brain regions (55.6%). In binary logistic regression analysis, each 1SD-increase in adiponectin level was significantly conversely associated with the prevalence of CMBs after adjusting for age, sex and cardiovascular risk factors (OR = 0.55; 95% CI: 0.36-0.84); but sE-selectin was significantly positively associated with the prevalence of CMBs (OR = 1.09; 95% CI: 1.02-1.15). Furthermore, partial correlation analyses showed that sE-selectin remained significantly associated with and correlated conversely to adiponectin (r = 鈭?#xA0;0.452, p = 0.001).
Conclusions
Endothelial injury may play a role in the pathogenesis of CMBs, and serum levels of adiponectin and sE-selectin were closely related to CMBs. Adiponectin might be protective for the prevalence of CMBs.